The most common variations in individuals or populations of all species are single nucleotide polymorphisms (SNPs) and copy number variations (CNVs). In humans, these genetic variations can be a principal cause for disease predisposition or risk factors for a number of disorders, illness severity, susceptibility to environmental factors (such as infectious agents or allergens) or drug treatment responses. The status of certain SNPs has been utilized to predict variable responses to therapeutics in individual patients. Thus, SNPs and CNVs have enormous significance in biomedical research and in developing pharmaceutical products or medical diagnostics (biomarkers).
ACGT possesses several genotyping platforms, including Illumina and Applied Biosystems. This combination of instruments can be used for reliable genotyping of any number of SNPs from just a few to several million, thus supporting validation and screening projects on any scale. ACGT provides solutions for a wide variety of genotyping areas, such as CNV analysis, microsatellite (STR) analysis, and DNA-based identification.
Our staff scientists work closely with our clients to develop customized strategies for each particular genotyping project.
Genotyping Applications We Support
- Genotyping Arrays
- Large Scale SNP analysis
- TaqMan® Genotyping Assays
- Genotyping by PCR
- Genotyping By Sanger Sequencing
- STR Genotyping
Additional testing methodologies we provide include:
- RFLP analysis
- Reverse field gel electrophoresis for sizing of large DNA fragments
- Non-radioactive dot blot and Southern blot assays
- Multiplex Ligation-dependent Probe Amplification (MLPA) for analysis of very large genomic indels
Please inquire if interested.